During recent years, there have been efforts in developing Natiocrystaline Calcium orthophosphate to enhance their biological and mecha.uical properties for use in biomedical applications. Calcium orthophosphate based inorganic bio ceramic materials have a wide range of biomedical applications pl. Bioresmbahle and Bioadive phases of calcium phosphate biocerarnic materialsr are choice for bone-tissue engineering application because of their similar inorganic composition with the mineral phases of natural bone, excellent biocortipatibility and osteoconductivity [2,3]. In 1920 it is repotted the first successful medical application of calcium phosphate in humans [41. Recently most widely-used hioresorbable and bioa.ctive ceramics include calcium orthophosphates (CaP). They are present in bones, teeth and the tendons of mammals. giving these organs hardness and stability. They are known as non-ion-substituted calcium orthophosphates with a Ca-P molar ratio ‘between 0.5 and 2.0_ The most widely used member of the family of Caps is hydmxyapatite (HA) [5]. Among different (onus of calcium phosphate. hydroxyapatite (HA) is one of the most promising inorganic bioniaterials, HA is the principal mineral constituents of natural hones and teeth [IS], Hydroxyapatite (HA) has been widely used as a hiomaterial in orthopedics. bioengineering and dentistry. because of its good biocompatibility [7]_ Synthetic Hydroxyapatite (HA) is the most promising because of good cation exchange rate with metals_ excellent biocompahibility and high affinity for the pathogenic microorganisms [8-101. It is reported that around 70-80% of implants are made of bi000mpatible metals [11]_ With lie introduction of a tmnsient metal ion such as silver HA can be effective in controlling mica-oorganisms Due to its ion-exchange capabilities.
